C038 Cloxacillin sodium/邻氯青霉素钠

Cloxacillin sodium/邻氯青霉素钠
产品编号：C038 
产品规格：1g

CAS Number	7081-44-9
Molecular Formula	C19H17ClN3NaO5S · H2O
Molecular Weight	475.88 g/mol
Form	Powder
Appearance	White or almost white powder
Purity Level	≥95.0%
Solubility	Water: Freely soluble
Source	Semi-synthetic
Water Content (Karl Fisher)	3.0-5.0%
pH	4.5-7.5
Boiling Point	689.7 °C
Melting Point	170 °C
Flash Point	370.9 °C
Storage Conditions	2-8 °C.

Description
Cloxacillin sodium is a narrow spectrum β-lactam antibiotic of the penicillin class. Cloxacillin sodium is freely soluble in aqueous solution (0.014 mg/mL).
Mechanism
β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases. Unlike other members of the penicillin class, cloxacillin is resistant to β-lactamases.
Spectrum
Cloxacillin targets primarily gram positive bacteria, especially β-lactamase producing Staphylococci.
Microbiology Applications