Asc-123 Aminoguanidine hydrochloride/肼甲酰亚胺酰胺一氯化氢

Biological Description

Irreversible inhibitor of iNOS, displaying 26-fold selectivity over nNOS. In vitro and in vivo inhibitor of the formation of glycosylation end products associated with diabetes and aging.

Useful References

Moore & Handy (1997) selective inhibitors of neuronal nitric oxide synthase--is no NOS really good NOS for the nervous system? Trends Pharmacol Sci 18:204-11 abstract



Stefanovic-Racic (1995) Comparison of the nitric oxide synthase inhibitors methylarginine and aminoguanidine as prophylactic and therapeutic agents in rat adjuvant arthritis. J Rheumatol 22:1922-8 abstract



Nilsson et al (1999) Biological effects of aminoguanidine: an update. Inflamm Res. 48:509-15. abstract

 

Chemical Information

Guanylhydrazine hydrochloride

• Store at RT


• MW 110.55


• Soluble in water to 100 mM


• CH₆N₄.HCl


• 1937-19-5


•