Asc-095 AM404/丙烯酰胺404

Biological Description

Competitive and selective anandamide transport inhibitor (IC₅₀ = 1 μM). Active in vivo. Does not activate CB₁ receptors or inhibit anandamide hydrolysis but has been shown to activate vanilloid receptors.

Useful References

Beltramo et al (1997) Functional role of high-affinity anandamide transport, as revealed by selective inhibition. Science 277:1094-7 abstract



Zygmunt et al (2000) The anandamide transport inhibitor AM404 activates vanilloid receptors. Eur.J.Pharmacol. 396:39-42 abstract



Bortolato et al (2006) Anxiolytic-like properties of the anandamide transport inhibitor AM404. Neuropsychopharmacology. 2006 31:2652-9. abstract

 

Chemical Information

(5Z,8Z,11Z,14Z)-N-(4-Hydroxyphenyl)icosa-5,8,11,14-tetraenamide

• Desiccate at -20°C


• MW 395.58


• Soluble in DMSO to 50mM and in ethanol to 50mM


• C₂₆H₃₇NO₂


• 198022-70-7