Asc-110 (-)-Bicuculline methochloride/(-)- 甲基氯化荷包牡丹碱

Biological Description

Water-soluble GABA_A antagonist. Methochloride salt of (+)-bicuculline (Asc-107). Actions on neuronal Ca²⁺-activated K⁺ channels reported.

Useful References

Olsen et al (1976) Studies on the neuropharmacological activity of bicuculline and related compounds. Brain Res 102:283-99 abstract



Seutin et al (1999) Recent advances in the pharmacology of quaternary salts of Trends Pharmacol Sci 20:268-70 abstract





 

Chemical Information

[S-(R*,S*)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium chloride

• Desiccate at +4°C


• MW 417.84


• Soluble in water to 100 mM


• C₂₁H₂₀ClNO₆


• 53552-05-9