B020 Bleomycin B2 sulfate, EvoPure/硫酸博来霉素B2, EvoPure

Bleomycin B2 sulfate, EvoPure/硫酸博来霉素B2, EvoPure
产品编号：B020 
产品规格：1mg/5mg/10mg

CAS Number	9041-93-4
Molecular Formula	C55H84N20O21S2 · H2SO4
Molecular Weight	1523.59 g/mol
Appearance	White or cream-colored amorphous powder
Purity Level	≥99.0%
Solubility	Water: 20 mg/mL
Source	Streptomyces Verticillus
Melting Point	200-204 °C
Storage Conditions	2-8 °C

Description
Bleomycin B2 sulfate is one of two components found in the glycopeptide antibiotic bleomycin sulfate, a chemotherapeutic agent used for the treatment of Hodgkin's lymphoma. Bleomycin A2 and B2 are structurally similar and differ by a unique terminal amine group.
TOKU-E offers three forms of bleomycin: bleomycin sulfate (B005), bleomycin A2 sulfate, EvoPure? (B019), and bleomycin B2 sulfate, EvoPure? (B020). EvoPure? products are individual molecular fractions, most >99% pure.
Mechanism
Bleomycin acts as an anticancer agent by causing single stranded breaks in DNA. The exact mechanism is not well defined however; it is thought to chelate metallic ions to decrease enzyme activity and stability. This effect is believed to cause enzymes to react with oxygen producing free radicals which create single stranded breaks in deoxyribose sugar.
Cancer Applications
Common treatment for Hodgkin's lymphoma.
References