Amphotericin B solubilized (45% Amphotericin B, 35% Sodium Deoxycholate)
产品编号：A008
产品规格：500mg/5g/50g
| CAS Number | 1397-89-3 |
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| Molecular Formula | C47H73NO17 |
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| Molecular Weight | 924.08 g/mol |
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| Form | Powder |
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| Appearance | Yellow or orange powder |
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| Solubility | (250μg/ml in H2O) hazy yellow solution |
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| Source | Biosynthetic, produced by Streptomycetes nodosus M4575. |
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| Water Content (Karl Fisher) | ≥10.0% |
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| Storage Conditions | 2-8 °C, store protected from light. |
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Description
Amphotericin B is a polyene antifungal.
TOKU-E offers three forms of amphotericin B: amphotericin B, USP (A007), amphotericin B, EP (A064), and amphotericin B, solubilized (A008). Amphotericin B, USP and amphotericin B, EP are nearly insoluble in aqueous solution (0.750 mg/mL). Amphotericin B, solubilized is comprised of 45% amphotericin B, 35% sodium deoxycholate, 10% phosphate buffer.
Mechanism
Amphotericin B targets ergosterol in the fungal cell membrane and increases permeability. This alteration of the cell membrane is toxic to the fungus and leads to death.
Spectrum
Amphotericin B targets a wide range of susceptible fungi including Histoplasma, Coccidioides, and Cryptococcusspecies.
Microbiology Applications
Amphotericin B is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against a wide range of fungal specimens. Medical microbiologists use AST results to recommend antifungal treatment options for infected patients. Representative MIC values include:
Cryptococcus neoformans 0.625 μg/mL – 2.5 μg/mL
Histoplasma capsulatum 0.03 μg/mL - 2 μg/mL
For a complete list of amphotericin B MIC values, click here.
Plant Biology Applications
