Vancomycin hydrochloride, EvoPure/盐酸万古霉素, EvoPure
产品编号：V007
产品规格：500mg/1g
| CAS Number | 1404-90-6 |
|---|
| Molecular Formula | C66H75Cl2N9O24 |
|---|
| Molecular Weight | 1449.3 g/mol |
|---|
| Form | Powder |
|---|
| Appearance | White or light brown powder |
|---|
| Solubility | Acetone: Insoluble
Methanol: Moderately soluble
Higher Alcohols: Insoluble
Ether: Insoluble
Water: Freely soluble |
|---|
| Source | Streptomyces Orientalis |
|---|
| Storage Conditions | 2-8 °C |
|---|
Description
Vancomycin HCl is a bactericidal glycopeptide antibiotic.
TOKU-E offers two forms of vancomycin HCl: vancomycin HCl (V001) and vancomycin HCl, EvoPure? (V007). Both forms are sparingly soluble in aqueous solution (0.225 mg/mL). EvoPure? products are purified single antibiotic fractions, most >99% pure.
Mechanism
Vancomycin prevents peptidoglycan synthesis by two separate mechanisms. One mechanism prevents N-acetylmuramic acid (NAM) and N-acetylglucosamine (NAG) from linking together forming the peptidoglycan backbone. The second mechanism prevents crosslinking between amino acid residues in the peptidoglycan chain.
Spectrum
Vancomycin targets gram positive bacteria especially those which are resistant to a number of antibiotics. ((ex.) MRSA)
Microbiology Applications
Vancomycin HCl is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:Methicillin resistant Staphylococcus aureus (MRSA) 0.25 μg/mL - 2 μg/mL
Clostridium difficile 0.06 μg/mL - 4 μg/mL
For a complete list of vancomycin HCl MIC values, click here.Media Supplement
Vancomycin can be used as a selective agent in Columbia Blood Agar, a selective media for Campylobacter species.
Plant Biology Applications
Vancomycin is often used in Agrobacterium tumefaciens mediated transformations as a method to control its growth. It is sometimes used in combination with cefotaxime because of its synergic greater effect. Most studies do not describe any negative effects to the plant by using vancomycin, However, in a study done by Silva and Fukai (2001), lower efficiency of transformation was found at concentrations of 500 μg/ml.
Mammalian Biology Applications
