Asc-393 Risperidone/利培酮

Biological Description

Atypical antipsychotic agent. Potent 5HT_2A antagonist (K_i = 0.4 nM) . Also displays high affinity at D₂ receptors (K_i = 3.13 nM).

Useful References

Leysen et al (1988) Biochemical profile of risperidone, a new antipsychotic. J Pharmacol Exp Ther 247:661-70 abstract



Leysen et al (1994) Risperidone: a novel antipsychotic with balanced serotonin-dopamine antagonism, receptor occupancy profile, and pharmacologic activity. J Clin Psychiatry. 55 Suppl:5-12 abstract



Grant et al (1994) Risperidone. A review of its pharmacology and therapeutic potential in the treatment of schizophrenia. Drugs. 48:253-73.abstract



 

Chemical Information

3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl] ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

• Store at +4°C


• MW 410.48


• Soluble to 10 mM in DMSO and to 10 mM in ethanol


• C₂₃H₂₇FN₄O₂


• 106266-06-2