Asc-388 Topotecan hydrochloride/盐酸托泊替康

Biological Description

Topoisomerase I inhibitor. Water-soluble derivative of camptothecin (#Asc-115). Anticancer agent.

Useful References

Mathijssen et al (2002) Pharmacology of topoisomerase I inhibitors irinotecan (CPT-11) and topotecan. Curr Cancer Drug Targets. 2:103-23. abstract



Tanizawa et al (1994) Comparison of topoisomerase I inhibition, DNA damage, and cytotoxicity of camptothecin derivatives presently in clinical trials. J Natl Cancer Inst. 86:836-42. abstract







 

Chemical Information

(S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione monohydrochloride

• Desiccate at -20°C


• MW 457.91


• Soluble in water to 100 mM and in DMSO to 100mM


• C₂₃H₂₃N₃O₅.HCl


• 119413-54-6