Asc-356 Mifepristone/ 米非司酮

Biological Description

A cell-permeable synthetic steroid that acts as a potent selective antagonist of progesterone (PR) and glucocorticoid (GR) receptors in vitro and in vivo. Acts as a silent antagonist at PR and has a higher affinity than progesterone.

Useful References

Baulieu (1991) The antisteroid RU486: its cellular and molecular mode of action. Trends Endocrinol Metab. 2:233-9 abstract



Gagne et al (1985) RU 38486: a potent antiglucocorticoid in vitro and in vivo. J.Steroid Biochem. 23: 247-51 abstract



Mao et al (1992) Molecular mechanism of RU 486 action: a review. Mol.Cell.Biochem. 109: 1-8 



 

Chemical Information

(11b,17b)-11-[4-(Dimethylamino)phenyl]-17-hydroxy-17-(1-propynyl)-estra-4,9-dien-3-one

• Desiccate at +4°C


• MW 429.6


• Soluble to 100 mM in DMSO and to 50 mM in ethanol


• C₂₉H₃₅NO₂


• 84371-65-3