Norepinephrine Transporter Antibody

分子量：
55 KDa
细胞定位：

形式：
Protein G purified culture supernatant.
参考文献：
Klimek V, Stockmeier C, Overholser J, Meltzer HY, Kalka S, Dilley G, Ordway GA (1997)Reduced levels of norepinephrine transporters in the locus coeruleus in major depression. J.Neurosci. 17(21):8451-8458Kim CH, Hahn MK, Joung Y, Anderson SL, Steele AH, Mazei-Robinson MS, Gizer I, TeicherMH, Cohen BM, Robertson D, Waldman ID, Blakely RD, Kim KS (2006) A Polymorphism in thenorepinephrine transporter gene alters promoter activity and is associated with attention-deficithyperactivity disorder. Proc Nat’l Acad Sci USA 103(50):19164-9.
产品概述：
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.This product is a high quality Norepinephrine Transporter antibody.
功能：

总结：
Norepinephrine Transporter [NET] (or noradrenaline transporter (NAT)) is a monoamine transporter that transports the neurotransmitter noradrenaline from the synapse back to its vesicles for storage until later use. It also appears to transport the neurotransmitter dopamine in the same way, but to a lesser degree. Studies have shown a decrease in NET levels in the locus coeruleus in patients diagnosed with major depression (Klimek et al., 1997). Cocaine, amphetamines and many therapeutic antidepressants, such as the SNRIs (Serotonin-norepinephrine reuptake inhibitors) and the tricyclic antidepressants (TCAs) act to raise noradrenaline. Furthermore, deficits in the NET gene have been associated with ADHD (Kim et al., 2006).
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