分子量：
6kDa
细胞定位：
Antigen Cellular Localization:Sarcoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single- pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein
形式：
Liquid
参考文献：
Fujii J.,et al.J. Biol. Chem. 266:11669-11675(1991).Salvatore C.A.,et al.Submitted (MAR-1991) to the EMBL/GenBank/DDBJ databases.McTiernan C.F.,et al.J. Mol. Cell. Cardiol. 31:679-692(1999).Minamisawa S.,et al.Biochem. Biophys. Res. Commun. 304:1-4(2003).Kaliman P.,et al.J. Biol. Chem. 280:8016-8021(2005).
产品概述：
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.This product is a high quality PLN / Phospholamban antibody (N-Terminus).
功能：
Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation.
总结：
Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation.
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