商品分类：多克隆抗体
产品概述：Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation.
靶点/蛋白：Human PLN / Phospholamban.
来源：Goat
参考文献：Fujii J.,et al.J. Biol. Chem. 266:11669-11675(1991).Salvatore C.A.,et al.Submitted (MAR-1991) to the EMBL/GenBank/DDBJ databases.McTiernan C.F.,et al.J. Mol. Cell. Cardiol. 31:679-692(1999).Minamisawa S.,et al.Biochem. Biophys. Res. Commun. 304:1-4(2003).Kaliman P.,et al.J. Biol. Chem. 280:8016-8021(2005).
特异性：Human, Mouse, Rat, Rabbit, Monkey, Pig, Horse, Bovine, Dog
别名：Cardiac phospholamban, PLB, PLN, PLB
应用：ELISA (1:8000), IHC-P (3.75 μg/ml), WB (0.01-0.03 μg/ml)
简单描述：Goat Polyclonal PLN / Phospholamban Antibody (N-Terminus). Validated for use in WB, IHC-P, E.
详情：FunctionReversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation.Cellular_LocationSarcoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single- pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane proteinTissue_LocationHeart muscle (at protein level).
生物商城：http://www.annoron.com
办公电话：010-56256916
官方售后：400-965-8633
企业 QQ：3212874516、3198592576
地 址：北京大兴经济技术开发区(亦庄)同济中路7号兴盛国际A栋4层
温馨提示：不可用于临床ZL。
