品Pai:miltenyi，产品名称：Anti-GITR-APC, mouse 200 tests
CD357 (GITR) antibodies, mouse - Miltenyi Biotec
货号：130-102-389
Clone DTA-1 specifically recognizes mouse GITR (Glucocorticoid-induced TNF-receptor), a member of the TNF receptor superfamily also known as TNFRSF18. It is expressed at low levels on resting T lymphocytes and at high levels on CD4+CD25+ regulatory T cells (Tregs). Activation of T cells upregulates GITR expression. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production, as well as MAPKs and NF-κB activation. GITR plays an important role in the function of CD4+CD25+ Tregs.
| Clone | Isotype |
|---|---|
| DTA-1 | rat IgG2bκ |
