Oleyl Trifluoromethyl Ketone
- 品牌：APExBIO
- 型号：5mg/10mg/50mg
- 供应商：上海伟寰生物科技有限公司
- 供应商报价：￥533 - 4095
- 标签：Oleyl Trifluoromethyl Ketone、Oleyl Trifluoromethyl Ketone价格、Oleyl Trifluoromethyl Ketone厂家、、APExBIO、上海伟寰生物科技有限公司
产品库
| 规格： | 5mg | 产品价格： | ￥533.0 |
|---|---|---|---|
| 规格： | 10mg | 产品价格： | ￥936.0 |
| 规格： | 50mg | 产品价格： | ￥4095.0 |
| CAS号 | 177987-23-4 | ||
| 别名 | Heptadecyl Trifluoromethyl Ketone,OTK | ||
| 分子式 | C19H33F3O | 分子量 | 334.5 |
| 溶解性 | Soluble in DMSO | 储存条件 | Store at -20° |
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Oleyl Trifluoromethyl Ketone is a potent FAAH inhibitor [1][2].
Fatty acid amide hydrolase (FAAH) is a member of the serine hydrolase family of enzymes. FAAH is the principal catabolic enzyme for the fatty acid amides (FAAs) that hydrolyzes both oleamide and anandamide as well as several other fatty acid amides [2].
Oleyl Trifluoromethyl Ketone is an analog of oleic acid in which the COOH group is replaced by trifluoromethyl ketone. Oleyl Trifluoromethyl Ketone is a potent FAAH inhibitor in both human and rat. In transfected COS-7 cells, 10 μM oleyl trifluoromethyl ketone inhibited hydrolysis of oleamide by human and rat FAAH activities by 95.7% and 94.8%, respectively [2].
References:
[1]. Cravatt BF, Giang DK, Mayfield SP, et al. Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides. Nature. 1996 Nov 7;384(6604):83-7.
[2]. Giang DK, Cravatt BF. Molecular characterization of human and mouse fatty acid amide hydrolases. Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2238-42.
