DiscoveryProbe™ Neuroscience-related Compounds Panel

Compound Panel Contents

Catalog No.	Product Name	Summary	Targets	CAS Number	Smiles
A2098	PRX-08066 Maleic acid	5-HT2B receptor antagonist,potent and selective	Neuroscience|5-HT Receptor	866206-55-5	FC(C=C1)=C(C#N)C=C1CN(CC2)CCC2NC3=C(C=C(Cl)S4)C4=NC=N3.O=C(O)/C=C\C(O)=O
A8369	Atropine	MAChRs antagonist	Neuroscience|AChR	5908-99-6	CN1C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3.CN1C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3.O.OS(=O)(=O)O
A1664	Celecoxib	Selective cyclooxygenase-2 (COX-2) inhibitor	Neuroscience|COX	169590-42-5	CC1=CC=C(C=C1)C2=CC(=NN2C3=CC=C(C=C3)S(=O)(=O)N)C(F)(F)F
A3733	Pramipexole dihydrochloride	Dopamine receptor agonist	Neuroscience|Dopamine Receptor	104632-25-9	CCCNC1CCC2=C(C1)SC(=N2)N.Cl.Cl
A2700	10Panx	Panx-1 mimetic inhibitor	Neuroscience|Gap Junction	955091-53-9	CC(C)C(C(=O)NC(CC(=O)O)C(=O)NC(CO)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CCC(=O)N)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC3=CNC4=CC=CC=C43)N
A2623	VU 0364439	Positive allosteric mGluR-4 modulator	Neuroscience|GluR	1246086-78-1	C1=CC=C(C(=C1)NS(=O)(=O)C2=C(C=C(C=C2)NC(=O)C3=CC=CC=N3)Cl)Cl
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Advantages

• Available in stock with overnight delivery and free shipping over $500
• Cost-effective and competitive price to save your findings
• Potent, selective and cell-permeable in inhibiting or activating target molecules
• Diverse in chemical structure and route of administration (oral/i.m/i.v injection etc.)
• Detailed files describing potency, selectivity and applications etc.
• Supported by published data from top peer-reviewed journals
• Guaranteed high quality with NMR and HPLC validation

产品描述
A wide range of well-characterized bioactive molecules that covers various targets related to neuroscience, including 5-HT Receptor, Amyloid β, GABA and COX etc. Facilitate your research towards the insights of Alzheimer disease, Parkinson's disease and epilepsy etc. Applicable in cellular assays, animal models and drug screenings etc.
References
1. Noda M, Higashida H, Aoki S, Wada K. Multiple signal transduction pathways mediated by 5-HT receptors. Mol Neurobiol. 2004 Feb;29(1):31-9. 
Abstract 
5-HT receptors are probably the least well understood among the 5-HT receptors, but the authors found that 5-HT receptors couple to multiple signaling cascades. When the 5-HT receptors were expressed in undifferentiated C6 glioma cells, they modulated the level of second messengers. The author results indicate that 5-HT receptors couple to multiple second messenger systems and may contribute to the complicated physiological and pathophysiological states.