DiscoveryProbe™ Membrane Transporter/Ion Channel-related Compounds Panel

Compound Panel Contents

Catalog No.	Product Name	Summary	Targets	CAS Number	Smiles
A8455	Nilvadipine	Potent calcium channel blocker	Membrane Transporter/Ion Channel|Calcium Channel	75530-68-6	CC1=C(C(C(=C(N1)C#N)C(=O)OC)C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OC(C)C
A8351	VX-809	CFTR corrector	Membrane Transporter/Ion Channel|CFTR	936727-05-8	CC1=C(N=C(C=C1)NC(=O)C2(CC2)C3=CC4=C(C=C3)OC(O4)(F)F)C5=CC(=CC=C5)C(=O)O
A1855	Bumetanide	Inhibitor of Na+/K+/Cl- cotransporter	Membrane Transporter/Ion Channel|NKCC	28395-03-1	CCCCNC1=C(C(=CC(=C1)C(=O)O)S(=O)(=O)N)OC2=CC=CC=C2
A3100	(+)-MK 801	Potent NMDA antagonist	Membrane Transporter/Ion Channel|NMDA Receptor	70449-94-4	C[C@]1(N2)C3=C(C=CC=C3)C[C@@H]2C4=C1C=CC=C4
A3532	KN-93	CaMKII inhibitor,selective and competitive	Membrane Transporter/Ion Channel|P2X purinergic receptor	139298-40-1	CN(CC=CC1=CC=C(C=C1)Cl)CC2=CC=CC=C2N(CCO)S(=O)(=O)C3=CC=C(C=C3)OC
B7659	Psora 4	Potent KV1.3 channel blocker	Membrane Transporter/Ion Channel|Potassium Channel	724709-68-6	O=C1OC2=C(C=C1)C(OCCCCC3=CC=CC=C3)=C4C(OC=C4)=C2
B4798	Procainamide HCl	Na+ channel blocker; DNA methyltransferase 1 inhibitor	Membrane Transporter/Ion Channel|Sodium Channel	614-39-1	CCN(CC)CCNC(=O)C1=CC=C(C=C1)N.Cl
A8519	SB705498	TRPV1 antagonist,potent and selective	Membrane Transporter/Ion Channel|TRPV1	501951-42-4	C1CN(CC1NC(=O)NC2=CC=CC=C2Br)C3=NC=C(C=C3)C(F)(F)F
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Advantages

• Available in stock with overnight delivery and free shipping over $500
• Cost-effective and competitive price to save your findings
• Potent, selective and cell-permeable in inhibiting or activating target molecules
• Diverse in chemical structure and route of administration (oral/i.m/i.v injection etc.)
• Detailed files describing potency, selectivity and applications etc.
• Supported by published data from top peer-reviewed journals
• Guaranteed high quality with NMR and HPLC validation

产品描述
A wide range of well-characterized bioactive molecules that covers various targets related to membrane transporter/ion channel, including ATPase, calcium channel and CFTR etc. Facilitate your research towards the insights of heart diseases, cystic fibrosis and immune disorders etc. Applicable in cellular assays, animal models and drug screenings etc.
References
1. Berridge MJ, Bootman MD, Roderick HL. Calcium signalling: dynamics, homeostasis and remodelling. Nat Rev Mol Cell Biol. 2003 Jul;4(7):517-29. 
Abstract 
Ca2+ is a highly versatile intracellular signal that operates over a wide temporal range to regulate many different cellular processes. Rapid highly localized Ca2+ spikes regulate fast responses, whereas slower responses are controlled by repetitive global Ca2+ transients or intracellular Ca2+ waves. Ca2+ has a direct role in controlling the expression patterns of its signalling systems that are constantly being remodelled in both health and disease.
2. Sajja RK, Cucullo L. Altered glycaemia differentially modulates efflux transporter expression and activity in hCMEC/D3 cell line. Neurosci Lett. 2015 Jun 26;598:59-65. 
Abstract 
The impact of diabetes on BBB efflux transporters is less understood. In this study, we examined the effects of single or repeated episodes of hypo-and hyperglycemia on major BBB efflux transporters expression/function in human cerebromicrovascular endothelial cell line (hCMEC/D3). this study suggests a differential impact of altered glycemic conditions on major BBB drug efflux transporters expression/function, sensitive to the length of exposure (acute vs. repeated), with an implication for altered CNS drug disposition in diabetic population.