DiscoveryProbe™ JAK/STAT Signaling Pathway Compounds Panel

Compound Panel Contents

Catalog No.	Product Name	Summary	Targets	CAS Number	Smiles
A1367	AP26113	Potent ALK inhibitor	JAK/STAT Signaling|EGFR	1197958-12-5	CN(C)C1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=C(C(=N3)NC4=CC=CC=C4P(=O)(C)C)Cl)OC
A8199	PD153035 hydrochloride	Potent EGFR inhibitor	JAK/STAT Signaling|EGFR	153436-54-5	COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)Br)OC
A8247	Afatinib (BIBW2992)	Irreversible EGFR/HER2 inhibitor	JAK/STAT Signaling|EGFR	439081-18-2	CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4
B1104	AZD-9291	Mutated forms EGFR inhibitor	JAK/STAT Signaling|EGFR	1421373-65-0	CN1C=C(C2=NC(NC3=C(OC)C=C(N(CCN(C)C)C)C(NC(C=C)=O)=C3)=NC=C2)C4=C1C=CC=C4
A4148	NVP-BSK805 2HCl	JAK2 inhibitor, potent selective	JAK/STAT Signaling|JAK	1092499-93-8	C1CNCCC1N2C=C(C=N2)C3=NC4=C(C=CC=C4N=C3)C5=CC(=C(C(=C5)F)CN6CCOCC6)F.Cl.Cl
A4151	ZM 39923 HCl	JAK3 inhibitor,potent and selective	JAK/STAT Signaling|JAK	1021868-92-7	CC(C)N(CC1=CC=CC=C1)CCC(C2=CC3=CC=CC=C3C=C2)=O.Cl
A4193	SMI-4a	Potent Pim inhibitor	JAK/STAT Signaling|Pim	438190-29-5	C1=CC(=CC(=C1)C(F)(F)F)C=C2C(=O)NC(=O)S2
A2224	Stattic	STAT3 inhibitor,small-molecule and potent	JAK/STAT Signaling|STAT	19983-44-9	C1=CC(=CC2=C1C=CS2(=O)=O)[N+](=O)[O-]
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产品描述
A wide range of well-characterized bioactive molecules that covers various targets on the JAK/STAT signaling pathway, including EGFR, JAK and STAT etc. Facilitate your research towards the insights of differentiations, apoptosis, immunity and tumorigenesis etc. Applicable in cellular assays, animal models and drug screenings etc.