DiscoveryProbe™ Cardiovascular-related Compounds Panel

Compound Panel Contents

Catalog No.	Product Name	Summary	Targets	CAS Number	Smiles
A1009	ANP (1-11), rat	Vasodilator	Cardiovascular
A1041	Angiotensin (1-7)	Vasoconstriction peptide hormone	Cardiovascular	51833-78-4	CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)O)NC(=O)C(CC3=CC=C(C=C3)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(=O)O)N
A1042	Angiotensin II	Potent vasopressor and a powerful stimulus for production and release of aldosterone from the adrenal cortex.	Cardiovascular	68521-88-0	CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)O)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(=O)O)N.CC(=O)O
A1043	Angiotensin III (human, mouse)	Aldosterone stimulator	Cardiovascular	13602-53-4	CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)O)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)N
A1057	coagulation factor II (thrombin) B chain fragment [Homo sapiens]	Trypsin-like serine protease	Cardiovascular
A1105	BNP (1-32), human	Brain natriuretic peptide	Cardiovascular	114471-18-0
A1111	Endothelin-1 (1-15), amide, human	Vasoconstrictor agent	Cardiovascular
A1143	heparin cofactor II precursor (SERPIND1) fragment [Homo sapiens]	Thrombin inhibitor	Cardiovascular
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Advantages

• Available in stock with overnight delivery and free shipping over $500
• Cost-effective and competitive price to save your findings
• Potent, selective and cell-permeable in inhibiting or activating target molecules
• Diverse in chemical structure and route of administration (oral/i.m/i.v injection etc.)
• Detailed files describing potency, selectivity and applications etc.
• Supported by published data from top peer-reviewed journals
• Guaranteed high quality with NMR and HPLC validation

产品描述A wide range of well-characterized bioactive molecules that covers various targets related to cardiovascular system, including angiotensin and thrombin etc. Facilitate your research towards the insights of vascular disease, stroke, wound repair and cancer etc. Applicable in cellular assays, animal models and drug screenings etc.
References1. Dasgupta C, Zhang L. Angiotensin II receptors and drug discovery in cardiovascular disease. Drug Discov Today. 2011 Jan;16(1-2):22-34. doi: 10.1016/j.drudis.2010.11.016. Epub 2010 Dec 13. 
Abstract 
Angiotensin II type 1 (AT1R) and type 2 (AT2R) receptors are expressed in most organs and tissues and are implicated in hypertension, endothelial dysfunction, and cardiovascular diseases. Certain variants of AT1R and AT2R are constitutively predisposed to higher cardiovascular risk and hypertension. In this review we focused on the structure, expression of angiotensin II receptors, their mode of action, role in cardiovascular pathobiology, and how cardiovascular diseases are programmed in utero. In addition, we described genetic variants of angiotensin receptors, and also discussed possible ways of therapeutic intervensions of Ang II stimulation.