商品分类：单克隆抗体
产品概述：Stat3 is a member of a group of proteins (Signal Transduction and Activators of Transcription) that act as both signal transducers for cytokines and growth factors, as well as transcription factors (1,2). Stats are activated by tyrosine phosphorylation in response to different ligands, after which they translocate to the cell nucleus (1). Stat3 is constitutively activated in a number of human tumors (3). Stat3 is activated by phosphorylation on tyrosine 705 which induces dimerization, nuclear translocation, and DNA binding Meanwhile, Stat3-activated transcription seems to be regulated by serine phosphorylation at serine 727 (4).
靶点/蛋白：A synthetic phospho-peptide corresponding to residues surrounding tyrosine 705 of human Stat3 was used as immunogen.
来源：Rabbit
存储溶液：50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
参考文献：1. Heim, M.H. J. Recept. Signal Transduct. Res. 19: 75
2. Kisseleva, T. et al. Gene 285: 1
3. Bromberg, J.F. et al. Cell 98: 295
4. Wen, Z. et al. Cell 82: 241
特异性：Human, Mouse
别名：Signal transducer and activator of transcription 3, Acute-phase response factor, STAT3, APRF
应用：WB~~1:10000~20000IHC~~1:100~250
简单描述：Rabbit Monoclonal Stat-3 Antibody Phospho (pY705). Validated for use in WB, IHC, IF. Clone: EP2147Y.
详情：FunctionSignal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute- phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity).Cellular_LocationCytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3 Identified in a complex with LYN and PAG1Tissue_LocationHeart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas
生物商城：http://www.annoron.com
办公电话：010-56256916
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地 址：北京大兴经济技术开发区(亦庄)同济中路7号兴盛国际A栋4层
温馨提示：不可用于临床ZL。
