商品分类：单克隆抗体
产品概述：Phospholamban is a major substrate for the cAMP-dependent kinase in cardiac muscle. It regulates the activity of the calcium pump of cardiac sarcoplasmic reticulum. It inhibits cardiac muscle sarcoplasmic reticulum Ca2+-ATPase in the unphosphoyrlated state, but inhibition is relieved upon phosphorylation of the protein (1). Beta-adrenergic stimulation results in PLB phosphorylation by both cAMP-dependent protein kinase at Serine 16 and calcium/calmodulin-dependent protein kinase at Serine 17 (2). Phospholamban is expressed in slow twitch skeletal muscle and some smooth muscle as well as in cardiac muscle (1).
靶点/蛋白：A phospho specific peptide corresponding to residues surrounding Serine 16 of human Phospholamban was used as an immunogen.
来源：Rabbit
存储溶液：50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
参考文献：1. Fujii, et al. J. Biol. Chem., 266(18):11669-11675, 1991. 2. Wegener et al, J Biol Chem. 1989; 264:11468-11474.
特异性：Human, Mouse
别名：Cardiac phospholamban, PLB, PLN, PLB
应用：WB~~1:200000~500000
简单描述：Rabbit Monoclonal Phospholamban Antibody Phospho (pS16). Validated for use in WB. Clone: EPR1911.
详情：FunctionReversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation.Cellular_LocationSarcoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single- pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane proteinTissue_LocationHeart muscle (at protein level).
生物商城：http://www.annoron.com
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企业 QQ：3212874516、3198592576
地 址：北京大兴经济技术开发区(亦庄)同济中路7号兴盛国际A栋4层
温馨提示：不可用于临床ZL。
