| Human Brain Cancer miRNA PCR Array: MIHS-108Z | | |
The Human Brain Cancer miScript miRNA PCR Array profiles the expression of 84 miRNAs known to alter their expression during nervous system-related carcinogenesis. This array provides cancer researchers with a convenient way to quickly analyze the miRNAs most relevant to brain and central nervous system tumorigenesis. Brain tumors, which cause uncontrolled cellular growth in the cranium or spinal column, involve any of the cell types found in the brain, such as neurons, glial cells, astrocytes, or cells of the meninges. By attenuating gene expression, miRNAs regulate many biological functions, and some, such as those in the miR-17-92 cluster, have known oncogenic properties. Expression studies of different brain tumor types have identified dysregulated miRNA; however, few are functionally linked to pathogenic mechanisms. Research into the functional consequences of miRNA dysregulation during neurocarcinogenesis may yield insights into the molecular mechanisms behind the pathogenesis of brain tumors. The array contains miRNAs with known functional consequences as well as miRNAs with a significant dysregulation but unknown function during oncogenesis. The profiling results from this array may yield insights into the molecular mechanisms behind the pathogenesis of multiple nervous system cancers. A set of controls present on this array enables data analysis using the ΔΔCT method of relative quantification, assessment of reverse transcription performance, and assessment of PCR performance. Using SYBR Green-based real-time PCR, the expression of a focused panel of miRNAs related to brain cancer can be easily and reliably analyzed with this miScript miRNA PCR Array.
miScript miRNA PCR Arrays are intended for molecular biology applications. This product is not intended for the diagnosis, prevention or treatment of a disease.
96-well, 384-well ( 4 x 96 ), and Rotor-Disc 100 formats are available.
See the complete miRNA PCR Array list | | |
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Anaplastic Astrocytoma: miR-107, miR-10b-5p, miR-124-3p, miR-125b-5p, miR-127-5p, miR-129-5p, miR-137, miR-138-5p, miR-187-3p, miR-203a, miR-218-5p, miR-296-5p, miR-31-5p, miR-320a, miR-7-5p.
Glioblastoma: miR-101-3p, miR-107, miR-10b-5p, miR-124-3p, miR-128, miR-129-5p, miR-130a-3p, miR-132-3p, miR-133a, miR-133b, miR-137, miR-138-5p, miR-149-5p, miR-153, miR-16-5p, miR-181a-5p, miR-181b-5p, miR-185-5p, miR-187-3p, miR-191-5p, miR-203a, miR-21-5p, miR-210, miR-218-5p, miR-221-3p, miR-222-3p, miR-222-5p, miR-23a-3p, miR-23b-3p, miR-25-3p, miR-29b-3p, miR-31-5p, miR-323a-5p, miR-328, miR-34a-5p, miR-425-5p, miR-451a, miR-486-5p, miR-7-5p.
Glioma: miR-106b-5p, miR-10b-5p, miR-128, miR-130b-3p, miR-144-3p, miR-146b-5p, miR-148a-3p, miR-15a-5p, miR-15b-5p, miR-16-5p, miR-17-5p, miR-181a-5p, miR-181b-5p, miR-182-5p, miR-183-5p, miR-184, miR-19a-3p, miR-200a-3p, miR-20a-5p, miR-21-5p, miR-210, miR-221-3p, miR-222-3p, miR-23a-3p, miR-25-3p, miR-26a-5p, miR-27a-3p, miR-296-5p, miR-328, miR-34a-5p, miR-451a, miR-486-5p, miR-9-5p, miR-9-3p, miR-93-5p.
Medulloblastoma: miR-106b-5p, miR-124-3p, miR-125a-5p, miR-125b-5p, miR-127-5p, miR-128, miR-129-5p, miR-130a-3p, miR-130b-3p, miR-133b, miR-137, miR-138-5p, miR-148a-3p, miR-150-5p, miR-153, miR-17-92 cluster (miR-17-5p, miR-18a-5p, miR-19a-3p, miR-20a-5p, miR-19b-3p, miR-92a-3p), miR-17-3p, miR-187-3p, miR-190a, miR-191-5p, miR-203a, miR-210, miR-216a-5p, miR-217, miR-218-5p, miR-25-3p, miR-29a-3p, miR-29b-3p, miR-30b-5p, miR-30c-5p, miR-320a, miR-323a-5p, miR-324-5p, miR-326, miR-328, miR-331-5p, miR-335-5p, miR-34a-5p, miR-425-5p, miR-7-5p, miR-9-3p, miR-93-5p, miR-96-5p.
Meningioma: let-7b-5p, miR-106a-5p, miR-106b-5p, miR-125a-5p, miR-153, miR-15a-5p, miR-181a-5p, miR-185-5p, miR-19b-3p, miR-200a-3p, miR-217, miR-23b-3p, miR-26a-5p, miR-27a-3p, miR-29a-3p, miR-335-5p, miR-451a.
Neuroblastoma: let-7b-5p, miR-106a-5p, miR-107, miR-125a-5p, miR-125b-5p, miR-128, miR-129-5p, miR-137, miR-141-3p, miR-146a-5p, miR-149-5p, miR-150-5p, miR-17-3p, miR-181a-5p, miR-181b-5p, miR-184, miR-187-3p, miR-190a, miR-200a-3p, miR-216a-5p, miR-221-3p, miR-23b-3p, miR-24-3p, miR-29a-3p, miR-29b-3p, miR-29c-3p, miR-30b-5p, miR-30c-5p, miR-320a, miR-323a-5p, miR-324-5p, miR-326, miR-331-5p, miR-335-5p, miR-34a-5p, miR-9-5p, miR-92a-3p, miR-93-5p.
Retinoblastoma: miR-320a.
