纤维化PCR芯片Fibrosis PCR Array

纤维化PCR芯片用于研究创伤修复和愈合中，被破坏的组织重构所涉及的84个关键基因的表达。创伤愈合包括三个时期：炎症期，肉芽期，组织重建期。在组织重建期，肌成纤维细胞通过细胞凋亡被清除，沉积的细胞外基质（ECM）被重塑，更像原始组织。若组织重塑异常，例如肌成纤维细胞异常生存或者ECM蛋白水解酶降解缺失，都有可能导致过量ECM沉积，则会造成纤维化。在纤维化的组织中，炎症反应和增强的TGFß信号通路，会导致细胞通过上皮间质转化（EMT）分化为肌成纤维细胞。与之相对的另一面，由于ECM降解被加强了，导致慢性损伤的组织重塑异常。芯片包括编码ECM重建酶基因，TGFß信号通路分子和炎症细胞因子，还包括其他与纤维化密切相关的基因。通过实时定量PCR的方法，研究者即能够利用该芯片简单可靠地同时检测纤维化和慢性损伤相关的基因表达。
 

Product	Species	Technology	Cat. No.
Fibrosis PCR Array	Human	Gene Expression	PAHS-120Z
Fibrosis PCR Array	Mouse	Gene Expression	PAMM-120Z
Fibrosis PCR Array	Rat	Gene Expression	PARN-120Z
Fibrosis PCR Array	Rabbit	Gene Expression	PANZ-120Z

Pro-Fibrotic: Acta2 (a-SMA), Agt, Ccl11 (Eotaxin), Ccl12, Ccl3 (MIP-1a), Ctgf, Grem1, Il13, Il13ra2, Snai1 (Snail). Anti-Fibrotic: Bmp7, Hgf, Ifng, Il10, Il13ra2. Extracellular Matrix & Cell Adhesion: ECM Components: COL1A2, COL3A1. Remodeling Enzymes: Lox, Mmp1a (Collagenase 1), Mmp13, Mmp14, Mmp2 (Gelatinase A), Mmp3, Mmp8, Mmp9 (Gelatinase B), Plat (tPA), Plau (uPA), Plg, Serpina1a (a1-antitrypsin), Serpine1 (PAI-1), Serpinh1, Timp1, Timp2, Timp3, Timp4. Cellular Adhesion: Itga1, Itga2, Itga3, Itgav, Itgb1, Itgb3, Itgb5, Itgb6, Itgb8 Inflammatory Cytokines & Chemokines:Ccl11 (Eotaxin), Ccl12, Ccl3 (MIP-1a), Ccr2, Cxcr4, Ifng, Il10, Il13, Il13ra2, Il1a, Il1b, Tnf. Growth Factors: Agt, Ctgf, Edn1, Egf, Hgf, Pdgfa, Pdgfb, Vegfa. Signal Transduction: TGFß Superfamily: Bmp7, Cav1, Dcn, Eng (EVI-1), Grem1, Inhbe, Ltbp1, Smad2, Smad3, Smad4, Smad6, Smad7, Tgfb1, Tgfb2, Tgfb3, Tgfbr1 (ALK5), Tgfbr2, Tgif1, Thbs1, Thbs2. Transcription Factors: Cebpb, Jun, Myc, Nfkb1, Sp1, Stat1, Stat6. Epithelial-to-Mesenchymal Transition: Akt1, Bmp7, Col1a2, Col3a1, Itgav, Itgb1, Mmp2 (Gelatinase A), Mmp3, Mmp9, Serpine1 (PAI-1), Smad2, Snai1 (Snail), Tgfb1, Tgfb2, Tgfb3, Timp1. Others: Bcl2, Fasl (TNFSF6).