囊性纤维化PCR芯片Cystic Fibrosis PCR Array

囊性纤维化PCR芯片可用于分析在囊性纤维化（CF）差异表达或与囊性纤维化跨膜电导调节（CFTR）相互作用的84个关键基因的表达。CFTR的突变会引起消化系统和呼吸系统的失调，CF患者会有不同程度的支气管粘液增厚，以及慢性肺炎导致的肺纤维化和肺功能衰竭目前的研究集中在患者逐渐恶化的CF肺部病变，通过ZL可以延长CF患者40年的平均寿命，但导致疾病及其症状的分子机制尚未发掘。这一芯片包含了离子转运蛋白基因、参与免疫或炎症反应的基因、可能与CFTR功能有关的基因。通过实时定量PCR的方法，研究者即能够利用该芯片简单可靠地同时检测CFTR分子机制相关基因的表达。
 

Product	Species	Technology	Cat. No.
Cystic Fibrosis PCR Array	Human	Gene Expression	PAHS-167Z
Cystic Fibrosis PCR Array	Mouse	Gene Expression	PAMM-167Z
Cystic Fibrosis PCR Array	Rat	Gene Expression	PARN-167Z

Modifier Genes: ADIPOR2, ADRB2, EDNRA, GCLC, GSTM1 (MGST1), IFRD1, IL8, MBL2, MSRA, NOS3 (eNOS), SCNN1B, SCNN1G, SERPINA1, TCF7L2, TGFB1, TNF, TNFRSF1A. Genes Interacting with CFTR: AHSA1, CANX, CFTR, DNAJA1, DNAJC5, EZR, GOPC, HSP90AA1, HSPA4 (HSP70), HSPA8, NME1 (NM23A), PDZK1, PPP2R4, PRKAA1, PRKAA2, SLC26A3, SLC9A3R1, SLC9A3R2, SNAP23, STX1A, STX8, TGFB1, TJP1, VCP. Neutrophil Chemotaxis: CCL2 (MCP1), CXCR2 (IL8RB), EDN1, EDNRA, IL1B, IL8, ITGB2. Inflammatory Response: ACE, ADRB2, ALOX12B, CCL2 (MCP1), CXCL1, CXCL2, DEFB1, EDNRA, IL10, IL1B, IL6, IL8, ITGB2, MBL2, NFKB1, PLA2G5, PTGS2 (COX2), S100A8, SERPINA1, TGFB1, TLR2, TLR4, TLR5, TNF, TNFRSF11A (RANK), TNFRSF1A. Immune Response: Innate: CCL2 (MCP1), CLU, DEFB1, ICAM1, LCN2 (NGAL), MAPK1 (ERK2), MBL2, NFKB1, NFKBIA (I?Ba), PRKCE, TGFB1, TLR2, TLR4, TLR5, TNFSF10 (TRAIL). Adaptive: CLU, FAS (TNFRSF6), ICAM1, IL10, IL1B, IL7R, MBL2, TGFB1, TLR4, TNF, TNFRSF11A (RANK). Unfolded Protein Response: CALR, DNAJA1, HSP90AA1, HSPA1A, HSPA4 (HSP70), HSPA8, HSPH1 (HSP105), VCP. Ion Binding & Transport: ADK, KCNE1, NR4A2 (NUR77), SCNN1B, SCNN1G, SLC9A3R1. Oxidative Stress: CLU, DUSP1 (PTPN16), GCLC, IL6, LCN2 (NGAL), MBL2, MSRA, NOS3 (eNOS), PTGS2 (COX2), SFTPB. Other Genes: EPSTI1, IGFBP5, ITGA2, KIT (CD117), MET, PRTN3, SLPI.