IMUBIND® Plasma PAI-1 ELISA（血浆纤溶酶原激活剂YZ物PAI-1酶联免疫试剂盒）

INTENDED USE
The IMUBIND® Plasma PAI-1 ELISA is an enzyme-linked immunosorbent assay for the measurement of human Plasminogen Activator Inhibitor Type-1 (PAI-1) antigen in plasma.
This kit is for in vitro diagnostic use.

EXPLANATION OF THE TEST
Plasminogen Activator Inhibitor Type-1 (PAI-1), a primary regulator of fibrinolysis, has been found in a number of different tissues, and cell types including macrophages/monocytes, hepatocytes, vascular endothelia, adipose tissue of the heart and lungs, and in platelets.1,2 The clinical interest in measuring PAI-1 in plasma is based on case studies in which levels of this serine protease inhibitor are associated with various thrombotic and fibrinolytic complications. Deficiency of PAI-1 activity is associated with bleeding disorders wherein the routine hemostatic screening tests are normal.3,4 High levels of PAI-1 activity are found in patients suffering from myocardial infarction, hemolytic uremic syndrome, and stroke.5-9 Levels of PAI-1 in the plasma of pregnant women are also correlated with gestational diabetes, reduced placental blood flow and preeclampsia.10,11,12 Patients with cirrhosis may also have elevated levels of PAI-1.13