Asc-235 SB 203580 hydrochloride

Biological Description

Water soluble, cell permeable p38 MAP kinase inhibitor. Shows selectivity over many other kinases but also shown to have some inhibitory activity against GAK, CK1 , RIP2 c-Raf and GSK3.

Useful References

Kumar et al (1999) Pyridinylimidazole compound SB 203580 inhibits the activity but not the activation of p38 mitogen-activated protein kinase. Biochem Biophys Res Commun.263:825-31 abstract



Cuenda et al (2007) p38 MAP-kinases pathway regulation, function and role in human diseases. Biochim Biophys Acta. 1773:1358-75 abstract



Bain et al (2007) The selectivity of protein kinase inhibitors: a further update. Biochem J. 408:297-315 abstract

 

Chemical Information

4-[4-(4-Fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]pyridine hydrochloride

• Desiccate at +4°C


• MW 413.90


• Soluble to 25 mM in Water


• C₂₁H₁₆FN₃OS.HCl


• 152121-47-6 (free base)