商品分类：多克隆抗体
来源：Goat
存储溶液：0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
参考文献：Progenitor cell maintenance requires numb and numblike during mouse neurogenesis. Petersen PH, Zou K, Hwang JK, Jan YN, Zhong W. Nature. 2002 Oct 31;419(6910):929-34. PMID: 12410312
特异性：Human
别名：Numb-like protein, Numb-related protein, Numb-R, NUMBL
简单描述：Goat Polyclonal NUMBL Antibody (N-Term). Validated for use in WB, E.
详情：FunctionPlays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF- kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.Cellular_LocationCytoplasm. Note=Symmetrically distributed throughout the cytoplasm in non dividing neuroblasts of the CNS.
生物商城：http://www.annoron.com
办公电话：010-56256916
官方售后：400-965-8633
企业 QQ：3212874516、3198592576
地 址：北京大兴经济技术开发区(亦庄)同济中路7号兴盛国际A栋4层
温馨提示：不可用于临床ZL。
