商品分类：多克隆抗体
产品概述：Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis- inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.
靶点/蛋白：peptide (SDEGADQEEEAYLRED) corresponding to amino acids 222 to 237 of murine Smac/DIABLO
来源：Rabbit
参考文献：Du C.,et al.Cell 102:33-42(2000).Srinivasula S.M.,et al.J. Biol. Chem. 275:36152-36157(2000).Fu J.,et al.J. Biol. Chem. 278:52660-52672(2003).Ota T.,et al.Nat. Genet. 36:40-45(2004).Scherer S.E.,et al.Nature 440:346-351(2006).
特异性：Human, Mouse
别名：Diablo homolog, mitochondrial, Direct IAP-binding protein with low pI, Second mitochondria-derived activator of caspase, Smac, DIABLO, SMAC
应用：IHC-P (5 μg/ml), WB (0.5-1 μg/ml),
简单描述：Rabbit Polyclonal DIABLO / SMAC Antibody (aa222-237). Validated for use in WB, IHC-P.
详情：FunctionPromotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis- inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.Cellular_LocationMitochondrion. Note=Released into the cytosol when cells undergo apoptosisTissue_LocationUbiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes. Isoform 3 is ubiquitously expressed
生物商城：http://www.annoron.com
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温馨提示：不可用于临床ZL。
