CD3-zeta Antibody Phospho (pY83) | LM20149 | Leading Biology

商品分类：单克隆抗体

产品概述：CD3 (Cluster of Differentiation 3) is a complex of proteins that associates directly with the T cell antigen receptor (TCR) (1). Antigen binding to the TCR leads to IL-2 secretion via activation of a tyrosine phosphorylation pathway and a phospholipase C (PLC) pathway, in turn activating protein kinase C (1,2). CD3 is composed of five invariant polypeptide chains that associate to form three dimers. The five invariant chains of CD3 are labeled gamma, delta, epsilon, zeta, and eta. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways (3). Loss of the zeta chain results in the synthesis of unstable TCRs (4). The reversible phosphorylation of tyrosine residues is an important mechanism for modulating biological processes such as cellular signaling, differentiation, and growth, and if deregulated, can result in various types of cancer (5).

靶点/蛋白：A phospho specific peptide corresponding to residues surrounding tyrosine 83 of human CD3 zeta was used as an immunogen. This antibody detects CD3 zeta phosphorylated on tyrosine 83.

来源：Rabbit

存储溶液：50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

参考文献：1. Weiss, A., et al. Sem. Immunol. 3: 313
2. Siegel, J.N., et al. Sem Immunol. 3: 325
3. Irving, B. A., and Weiss, A. (1991) Cell 64, 891-901
4. Minami, Y., Weissman, A.M., Samelson, L.E., and Klausner, R.D. 1987.Natl. Acad. Sci. USA. 84:2688-2692
5. Saloman AR, et al. Proc Natl Acad Sci 100(2):443-8, 2003


特异性：Human

别名：T-cell surface glycoprotein CD3 zeta chain, T-cell receptor T3 zeta chain, CD247, CD247, CD3Z, T3Z, TCRZ

应用：WB~~1:500

简单描述：Rabbit Monoclonal CD3-zeta Antibody Phospho (pY83). Validated for use in WB. Clone: EP776(2)Y.

详情：FunctionProbable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering.Cellular_LocationMembrane; Single-pass type I membrane protein

生物商城：http://www.annoron.com

办公电话：010-56256916

官方售后：400-965-8633

企业 QQ：3212874516、3198592576

地 址：北京大兴经济技术开发区(亦庄)同济中路7号兴盛国际A栋4层