DiscoveryProbe™ GPCR/G protein-related Compounds Panel

Compound Panel Contents

Catalog No.	Product Name	Summary	Targets	CAS Number	Smiles
A8454	Istradefylline (KW-6002)	Selective A2A receptor antagonist	GPCR/G protein|Adenosine Receptor	155270-99-8	CCN1C2=C(C(=O)N(C1=O)CC)N(C(=N2)C=CC3=CC(=C(C=C3)OC)OC)C
B1007	AVE 0991	Agonist of angiotensin-(1-7) receptor	GPCR/G protein|Angiotensin Receptor	304462-19-9	CCNC(=O)NS(=O)(=O)C1=C(C=C(S1)CC(C)C)C2=CC=C(C=C2)CN3C(=C(N=C3C4=CC=CC=C4)OC)C=O
A1435	CP-945598 HCl	CB1 antagonist,selective and high affinity	GPCR/G protein|Cannabinoid Receptor	686347-12-6	CCNC1(CCN(CC1)C2=NC=NC3=C2N=C(N3C4=CC=C(C=C4)Cl)C5=CC=CC=C5Cl)C(=O)N.Cl
A5827	AM1241	Cannabinoid CB2 receptor agonist,potent and selective	GPCR/G protein|Cannabinoid Receptor	444912-48-5	CN1CCCCC1CN2C=C(C3=CC=CC=C32)C(=O)C4=C(C=CC(=C4)[N+](=O)[O-])I
A2025	Plerixafor (AMD3100)	CXCR4 antagonist; CXCR7 agonist	GPCR/G protein|CXCR	110078-46-1	C1CNCCNCCCN(CCNC1)CC2=CC=C(C=C2)CN3CCCNCCNCCCNCC3
A3802	SCH 527123	CXCR1 and CXCR2 receptors antagonist	GPCR/G protein|CXCR	473727-83-2	CCC(C1=CC=C(O1)C)NC2=C(C(=O)C2=O)NC3=CC=CC(=C3O)C(=O)N(C)C
B1633	CTEP (RO4956371)	MGlu5 inhibitor	GPCR/G protein|mGluR	871362-31-1	CC1=C(N=C(N1C2=CC=C(C=C2)OC(F)(F)F)C)C#CC3=CC(=NC=C3)Cl
A3616	MK-4305	OX1/OX2 atagonist,potent and selective	GPCR/G protein|OX Receptor	1030377-33-3	CC1CCN(CCN1C(=O)C2=C(C=CC(=C2)C)N3N=CC=N3)C4=NC5=C(O4)C=CC(=C5)Cl
B2166	Ticagrelor	P2Y12 receptor antagonist	GPCR/G protein|P2Y Receptor	274693-27-5	CCCSC1=NC2=C(C(=N1)NC3CC3C4=CC(=C(C=C4)F)F)N=NN2C5CC(C(C5O)O)OCCO
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Advantages

• Available in stock with overnight delivery and free shipping over $500
• Cost-effective and competitive price to save your findings
• Potent, selective and cell-permeable in inhibiting or activating target molecules
• Diverse in chemical structure and route of administration (oral/i.m/i.v injection etc.)
• Detailed files describing potency, selectivity and applications etc.
• Supported by published data from top peer-reviewed journals
• Guaranteed high quality with NMR and HPLC validation

产品描述
A wide range of well-characterized bioactive molecules that covers various targets related to GPCR, including adenosine receptor, adrenergic receptor and CXCR etc. Facilitate your research towards the insights of cancer, neurological disorders and heart diseases etc. Applicable in cellular assays, animal models and drug screenings etc.
References
1. Wettschureck N, Offermanns S. Mammalian G proteins and their cell type specific functions. Physiol Rev. 2005 Oct;85(4):1159-204. 
Abstract 
G protein-mediated signaling is employed by virtually all cells in the mammalian organism and is centrally involved in diverse physiological functions such as perception of sensory information, modulation of synaptic transmission, hormone release and actions, regulation of cell contraction and migration, or cell growth and differentiation. In this review, some of the functions of heterotrimeric G proteins in defined cells and tissues are described.