ABT-737、CAS号: 852808-04-9

 ABT-737的产品信息
英文名称：ABT-737，请联系客服QQ：1443869017获知 ABT-737的库存和报价。
上海赛鑫生物技术有限公司 供应美国原装进口：ABT-737
 所属分类：现货> -20摄氏度低温储备>
Bcl-2 YZ剂 >> ABT-737
 别名：N/A
分子式：C₄₂H₄₅ClN₆O₅S₂
分子量：813.43
CAS号：852808-04-9
物质化学性质：
 生物活性ABT-737 is a pan-Bcl-2 inhibitor that has a wide range of single-agent activity against acute lymphoblastic leukemia (ALL) cell lines and xenografts. Increased expression of the Bcl-2 family of proteins in cancers has been associated with chemotherapy resistance, ^[1-3] inhibiting Bcl-2 or Bcl-XL overexpression could potentially induce apoptosis in cancer cells while having minimal effects on normal cells. The ABT-737 single-agent LC90 values ranged from 100 nM for COG-LL-319 and RS4;11 cells to low micromolar concentrations for the other five ALL cell lines.
参考文献